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KMID : 1035320180450030155
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Korean Society for Dental Materials
2018 Volume.45 No. 3 p.155 ~ p.167
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Histomorphometric evaluation of bone healing capacity of epigallocatechin-3-gallate-loaded β-TCP bone substitute in rabbit calvarial defects
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Park Jin-Woo
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Abstract
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TCP-1 filled defects at 8 weeks. Histomorphometric analysis revealed significantly greater newly formed bone area in the TCP-1 group when compared with unloaded TCP-0 (p<0.05 at 4 and 8 weeks) and 10 mg EGCG-loaded TCP-10 groups (p<0.05 at 8 weeks). No difference was observed in new bone area between TCP-0 and TCP-10 groups. These results suggest that local delivery of 1 mg EGCG to β-TCP bone substitute by simple adsorption promotes bone regeneration in the healing of rabbit calvarial osseous defect and higher EGCG dose (in this study, 10 mg per defect) does not exert any positive effect on bone healing capacity of β-TCP. Thus, local delivery of EGCG to β-TCP bone substitute seems to be an effective approach for the treatment of osseous defects.
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KEYWORD
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Bone substitute, Bone regeneration, EGCG, Histomorphometry, Polyphenol
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